相关实验视频

Updated: Jun 30, 2025

A Minimally Invasive Method for Intratracheal Instillation of Drugs in Neonatal Rodents to Treat Lung Disease

A Minimally Invasive Method for Intratracheal Instillation of Drugs in Neonatal Rodents to Treat Lung Disease

Published on: August 4, 2021

与输入管,表面活性剂,早产新生儿的快速输出管方法相比,表面活性剂的侵袭性较小:一个总体审查

Ilari Kuitunen^1,2, Kati Räsänen^1,2

¹Department of Pediatrics and Neonatology, Kuopio University Hospital, Kuopio, Finland.

|March 19, 2024

概括

较少侵入性表面活性剂的使用 (LISA) 比输管,表面活性剂,新生儿的快速输管 (INSURE) 更有效,减少机械通风和死亡或支气管肺功能失调. 然而,研究质量往往很低.

科学领域:

新生儿医学新生儿医学
呼吸系统护理呼吸系统护理
基于证据的医学基于证据的医学.

背景情况:

表面活性剂替代疗法对于新生儿的呼吸困扰综合征至关重要.
有两种主要的施用方法:少侵入性表面活性剂施用 (LISA) 和输管,表面活性剂,快速输出 (INSURE).
对LISA与INSURE的有效性进行比较需要对现有证据进行综合分析.

研究的目的:

提供LISA与INSURE在自发呼吸新生儿中的疗效的概述.
综合了LISA与INSURE随机对照试验的元分析结果.

主要方法:

对元分析的综合审查,包括随机对照试验.
搜索了PubMed,Scopus和科学网络 (2023年7月).
包括系统审查与对比LISA和INSURE的元分析;使用AMSTAR-2和ROBIS评估质量.

主要成果:

包含了9个系统性审查和元分析.
在预防机械通风 (8/8评论) 和死亡或支气管肺形 (BPD) (4/4评论) 方面,LISA比INSURE更有效.
质量评估显示,大部分系统评审都存在缺陷,在九个评审中的六个中存在偏见的高风险.

结论:

在机械通风和死亡/BPD结合结果方面,LISA显示出比INSURE更高的疗效.
包含的系统性审查和元分析的整体质量主要是低到非常低的.
未来的研究应该优先考虑高质量的系统审查和强有力的报告标准.

关键词:

过早分娩过早分娩是什么肺部病理学肺部病理学呼吸困扰综合征是呼吸困扰综合征.表面活性剂是一种表面活性剂.

更多相关视频

A Novel Rescue Technique for Difficult Intubation and Difficult Ventilation

A Novel Rescue Technique for Difficult Intubation and Difficult Ventilation

Published on: January 17, 2011

An Improved Method for Rapid Intubation of the Trachea in Mice

An Improved Method for Rapid Intubation of the Trachea in Mice

Published on: February 22, 2016

相关概念视频

Endotracheal Intubation I: Procedure

Endotracheal Intubation I: Procedure

Endotracheal or ET intubation is a critical medical procedure used to secure a patient's airway, often in acute respiratory distress, apnea, upper airway obstruction, ineffective clearance of secretions, high risk for aspiration, or during general anesthesia.
The ET tube comprises various components, including a standard adaptor to attach a bag-valve-mask (BVM) or ventilator, a cuff, a pilot balloon, and radiopaque markings along its length to measure the insertion distance. The tube sizes...

Endotracheal Tube Extubation

Endotracheal Tube Extubation

Endotracheal tube extubation is a critical procedure in weaning patients from mechanical ventilation. It involves physically removing the oral or nasal endotracheal (ET) tube, marking the final step in liberating a patient from ventilatory support.
Procedure
Extubation removes the endotracheal tube (ETT) from the patient on mechanical ventilation. It requires a well-coordinated, multidisciplinary approach involving physicians, nurses, respiratory therapists, and other healthcare professionals....

Endotracheal Intubation II: Nursing Management

Endotracheal Intubation II: Nursing Management

Endotracheal intubation is a critical procedure that can be lifesaving for many patients with respiratory distress or failure. The role of nursing in managing endotracheal tubes is pivotal, as it involves pre-intubation preparation, assisting during the procedure, and post-extubation care.
1. Nursing Care of Patients Before Intubation
Before the endotracheal intubation procedure, nurses play an essential role in ensuring the process goes smoothly. The nurses must be familiar with intubation...

Breathing

Breathing

The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...

Mechanical Ventilation III: Noninvasive Ventilation

Mechanical Ventilation III: Noninvasive Ventilation

Noninvasive positive-pressure ventilation (NIPPV), continuous positive airway pressure (CPAP), and bilevel positive airway pressure (BiPAP) are essential methods in respiratory care. These ventilation techniques offer unique benefits for patients with various respiratory conditions, providing adequate support without requiring intubation. Let's explore how each method is crucial in improving patient outcomes and enhancing respiratory therapy.
Noninvasive Positive-Pressure Ventilation...

Mechanical Ventilation II: Invasive Ventilation

Mechanical Ventilation II: Invasive Ventilation

Ventilators are essential medical equipment used to aid patients with respiratory difficulties. Their primary function is to assist or replace spontaneous breathing by providing mechanical ventilation. There are two general classes of mechanical ventilators: negative-pressure and positive-pressure ventilators.
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...