基因预测加工肉类,红肉摄入量和精神疾病风险:一个多变量门德尔随机化分析
Mingkun Liu1, Wenwen Wang2, Yi Chen3
1Department of radiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital South Campus, Shanghai 201499, China.
Journal of affective disorders
|March 19, 2024
概括
基因预测牛肉摄入量可能会降低情绪障碍 (MD) 和严重抑郁症 (MDD) 的风险. 这项孟德尔随机化研究发现加工肉,猪肉或羊肉与心理健康状况之间没有显著的因果关系.
科学领域:
- 营养精神病学 营养精神病学
- 遗传流行病学遗传流行病学
- 心理健康研究 心理健康研究
背景情况:
- 观察性研究表明,加工和红肉消费与精神障碍之间存在联系.
- 这些关联的因果关系证据仍然不清楚.
- 门德尔随机化 (MR) 用于研究潜在的因果关系.
研究的目的:
- 检查基因预测加工肉和红肉摄入量对情绪障碍 (MD),焦虑障碍 (AD) 和严重抑郁障碍 (MDD) 的因果关系.
- 区分特定的红肉 (牛肉,猪肉,羊肉) 和加工肉对心理健康结果的影响.
主要方法:
- 使用来自英国生物银行的遗传仪器进行双样本孟德尔随机化 (MR) 分析.
- 关于MD,AD和MDD的关联数据来自FinnGen联盟.
- 逆方差加权 (IVW) 方法是主要的,以MR Egger,加权中位数和多变量MR (MVMR) 进行灵敏度和调整.
主要成果:
- 基因预测的牛肉摄入量显示了MD,AD和MDD的风险降低.
- 在MVMR分析中,在对其他肉类进行调整后,牛肉摄入量仍然对MD和MDD具有保护作用.
- 没有发现加工肉,猪肉或羊肉摄入量与精神障碍有显著的因果关系.
结论:
- 研究结果支持牛肉摄入量在降低情绪障碍和严重抑郁症的风险方面起因作用.
- 加工肉,猪肉和羊肉的摄入量似乎对所研究的精神障碍没有显著的因果关系.
- 灵敏度分析表明没有显著的水平形,加强了这些发现.
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