基于电路的神经调制增强了延迟回忆在amnestic轻度认知障碍中的延迟回忆
Jie Ma1,2, Jia-Jia Wu1,3, Xiang-Xin Xing1
1Center of Rehabilitation Medicine, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Journal of neurology, neurosurgery, and psychiatry
|March 19, 2024
概括
基于电路的配对关联刺激 (PAS) 改善了长期回忆力在患有无记忆性轻度认知障碍 (aMCI) 的成年人中. 在aMCI患者中这种认知增强可能与特定大脑电路中的功能连接性减少有关.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 临床神经学 临床神经学
背景情况:
- 轻度认知障碍 (aMCI) 影响记忆,是阿尔茨海默病的前体.
- 鉴定aMCI的有效干预措施对于延缓认知衰退至关重要.
- 非侵入性脑刺激技术显示出对认知增强的前景.
研究的目的:
- 评估基于电路的配对关联刺激 (PAS) 对改善MCI成人认知功能的疗效.
- 确定特定的大脑电路参与了PAS的认知效应.
- 探索功能连接和认知表现的变化之间的关系.
主要方法:
- 进行了一项并行组,随机,受控的临床试验.
- 扩散张力成像 (DTI) 用于在健康受试者中绘制皮质-海马体电路.
- aMCI患者接受了为期2周的基于电路的PAS或假的PAS,并进行认知评估和功能连接 (FC) 测量.
主要成果:
- 基于电路的PAS显著改善了听力口语学习测试 (AVLT) _N5分数与假的PAS相比 (p=0.003).
- hippocampus 和 precuneus 之间的功能连接 (FC),以及 hippocampus 和上额头,与AVLT_N5分数相关.
- 在干预后基于电路的PAS组中观察到左海马和左前之间CF的减少 (p=0.013).
结论:
- 基于电路的PAS是一种有效的干预措施,用于增强MCI (50-80岁) 成年人的长期延迟回忆.
- 观察到的认知改善可能与左海马前回路的功能连接性下降有关.
- 这项研究提供了针对性神经调节策略在管理aMCI.
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