工程工业酵母用于提高耐受性和强度
Zijian Wan1, Haibo Hu1, Kang Liu1
1State Key Laboratory of Materials-Oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, P.R. China.
Critical reviews in biotechnology
|March 19, 2024
概括
提高酵母菌对恶劣工业条件的耐受性是有效生物生产的关键. 本综述涵盖了诸如突变发生和代谢工程等策略,以提高酵母的强度,以实现可持续的代谢物制造.
科学领域:
- 工业生物技术 工业生物技术
- 微生物工程是微生物的工程.
背景情况:
- 工业酵母菌株是生产各种化合物的关键细胞工厂.
- 不利的条件 (有毒产品,pH,度) 限制了酵母生长和代谢性能,降低了发酵效率.
- 提高酵母耐受性和强度对于可靠和可持续的代谢物生产至关重要.
研究的目的:
- 综合审查改善酵母细胞对工业压力的耐受性战略.
- 为工业应用提供有关提高酵母强度的见解.
主要方法:
- 审查现有的关于提高酵母耐受性的策略的文献.
- 随机突变发生技术的讨论.
- 系统代谢工程方法的探索.
- 对物质介导固定细胞技术的研究.
主要成果:
- 确定了关键策略,包括随机突变发生,系统代谢工程和细胞固定.
- 强调了这些方法在克服工业生产局限性的重要性.
- 强调了酵母对环境压力的反应的智能调节的潜力.
结论:
- 提高酵母耐受性对于工业生物生产至关重要.
- 有多种策略可以提高酵母的强度.
- 进一步的研究可以导致酵母的智能调节,以实现可持续的制造.
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