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产前大麻使用障碍和加利福尼亚州的胃肠裂,2007-19

Erin Delker¹, Rebecca J Baer^1,2, Ann E Kelly¹

¹Department of Pediatrics, University of California San Diego, San Diego, CA, USA.

International journal of epidemiology

|March 19, 2024

概括

产前大麻使用障碍与高风险的 gastroschisis,一个出生缺陷. 这种关联在34岁以上的母亲中最强.

科学领域:

围产期健康围产期健康
有先天性异常.
生殖健康生殖健康

背景情况:

胃是一个先天性腹壁缺陷,原因不明.
最近的胃病流行趋势表明环境或行为因素.
调查产前物质使用,特别是大麻使用障碍,至关重要.

研究的目的:

为了检查产前大麻使用障碍和胃肠裂之间的关联.
要确定母亲的年龄是否会改变这种关联.

主要方法:

利用了母亲和婴儿队列 (2007-2019) 结果研究.
包括加利福尼亚州超过570万个独生子活产.
使用诊断和程序代码测量大麻使用障碍和胃.

主要成果:

大麻使用障碍的患病率约为1%.
在暴露于大麻使用障碍的婴儿中,胃分裂的患病率更高 (0.14%对比0.06%).
观察到一种积极的关联 (aRR=1.3-1.5),特别是在34岁以上的母亲身上 (aRR=2.5).

结论:

证实了产前大麻暴露和胃肠裂之间的积极关联.
这种关联在34岁以上的母亲中显著更强.
需要进一步的研究来确定因果关系,并了解与年龄相关的变化.

关键词:

大麻大麻大麻大麻大麻大麻大麻出生缺陷是一种出生缺陷.胃肠裂的发生.兄弟设计兄弟设计

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