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甲状腺癌的治疗方法

Luca Giovanella¹, Murat Tuncel², Atena Aghaee³

¹Department of Nuclear Medicine, Gruppo Ospedaliero Moncucco, Lugano, Switzerland; Clinic for Nuclear Medicine, University Hospital Zürich, Zürich, Switzerland.

Seminars in nuclear medicine

|March 19, 2024

概括

分子成像通过整合分子生物标志物和治疗疗法来完善甲状腺癌的管理,以提供个性化的治疗. 这种方法增强了风险分层,并指导各种类型的甲状腺癌的治疗,包括差异化,差异化和髓性甲状腺癌.

科学领域:

在瘤学瘤学.
核医学是一种核医学.
放射学放射学是一门学科.

背景情况:

分子成像对于评估和管理各种甲状腺癌组织型至关重要.
目前的甲状腺癌风险分层系统可以通过整合分子和分子成像生物标志物来改进.
在甲状腺癌管理中,治疗方法使得患者特定的治疗决策成为可能.

研究的目的:

审查分子成像和甲状腺癌中的治疗术的作用和未来前景.
突出分子成像如何改进不同类型的甲状腺癌亚型的风险分层和治疗策略.
讨论治疗晚期和转移性甲状腺癌的术术应用的进展.

主要方法:

分子成像技术的审查,包括放射性同位素 (I-131,I-123,I-124) 和PET/CT扫描 ([18F]FDG,6-[18F]FDOPA).
分析诸如再差异化疗法和受体治疗术之类的治疗术策略.
评估分子成像在风险分层和评估疾病的攻击性和转移.

主要成果:

放射性同位素是差异化甲状腺癌 (DTC) 风险分层的核心.
[18F]FDG PET/CT评估了DTC,差分化和形甲状腺癌的攻击性和转移.
6-[18F]FDOPA PET/CT对甲状腺髓癌 (MTC) 具有高度特异性;[18F]FDG PET/CT有助于攻击性的MTC表型.

结论:

分子成像,结合治疗术,为甲状腺癌患者提供个性化治疗.
新的再分化策略和受体异位学表明,对放射性耐火的DTC和MTC有希望.
整合分子成像生物标志物完善了甲状腺癌的管理,改善了患者的治疗结果.

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