癌症相关疲劳管理的微生物组修饰剂:系统性审查
Silvia Belloni1, Rosario Caruso2, Chiara Giacon3
1Gastroenterology Unit, IRCCS Humanitas Research Hospital, Rozzano, Italy.
Seminars in oncology nursing
|March 19, 2024
概括
益生菌和协生菌在治疗与癌症相关的疲劳 (CRF) 中显示出潜力. 需要进一步的大规模试验来确认它们在癌症治疗期间作为辅助疗法的有效性.
科学领域:
- 在瘤学瘤学.
- 微生物组研究 微生物组研究
- 营养科学 营养科学
背景情况:
- 与癌症相关的疲劳 (CRF) 显著影响患者的生活质量.
- 目前对CRF的管理策略存在局限性.
- 肠道微生物群在癌症及其治疗中的作用是一个新兴的兴趣领域.
研究的目的:
- 系统地审查有关益生菌在治疗癌症相关疲劳 (CRF) 的有效性的证据.
- 探索益生菌和共生菌作为癌症治疗中的辅助疗法的潜力.
主要方法:
- 随机对照试验 (RCT) 的系统审查.
- 在六个主要数据库 (PubMed,CINHAL,Cochrane,Web of Science,Scopus,EMBASE) 进行全面的文献搜索,截至2023年12月.
- 使用Cochrane RoB 2工具进行偏差风险评估,然后进行叙事综合和探索性元分析.
主要成果:
- 包括三项涉及284名患有结肠直肠癌和乳腺癌的参与者的研究.
- 益生菌在化疗后的结直肠癌患者的CRF中表现出边际至显著的改善.
- 在接受化疗的乳腺癌患者中,合成生物药物显著降低了CRF的严重程度.
结论:
- 初步证据表明,益生菌和共生菌可能作为CRF的辅助疗法有益.
- 更大的临床试验对于验证这些发现和指导临床实践至关重要.
- 护士可以利用微生物组修饰剂来增强癌症患者的护理和生活质量.
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