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克森托伯拉·博基 (Xenoturbella bocki) 的单细胞地图强调了有限的细胞类型复杂性

Helen E Robertson^1,2,3, Arnau Sebé-Pedrós^4,5,6, Baptiste Saudemont²

¹Department of Organismal Biology and Anatomy, The University of Chicago, Chicago, IL, USA.

Nature communications

|March 20, 2024

概括

这项研究揭示了海洋虫Xenoturbella bocki中保存的细胞类型,支持动物组织和Xenacoelomorpha属的单类的广泛同质性.

科学领域:

* 进化生物学进化生物学
*比较的基因组学
* 动物的动物学.

背景情况:

* Xenacoelomorpha属,包括小型海洋,最近通过遗传学分析确定.
* 它在双胞胎群中的地位仍在争论中,假设表明它与Ambulacraria (Xenambulacraria) 或整个双胞胎群 (Nephrozoa) 有姐妹关系.
*了解Xenacoelomorpha的细胞类型对于解决这些遗传学问题和追踪双边细胞类型进化至关重要.

研究的目的:

* 为了研究海洋形虫Xenoturbella bocki的细胞类型补充.
* 将Xenoturbella的细胞类型与其他元动物的细胞类型进行比较,以推断进化关系.
* 提供有助于评估Xenacoelomorpha的遗传位置的数据.

主要方法:

* 整个生物体单细胞RNA测序 (scRNA-seq) 在Xenoturbella bocki.cki上进行.
* 用生物信息分析来识别和描述细胞类型.
*对基因表达模式与其他动物类的比较分析.

主要成果:

* 仙布拉克拉神经网络表现出类似于类动物和原生体的调节特征和类身份.
*Xenoturbella的肌肉和腺细胞类型与其他元动物有很大相似之处.
*在Xenoturbella和肠道和表皮组织之间观察到特定的亲缘关系.

结论:

*这些发现支持动物腺体,肌肉和神经元细胞类型的广泛同质性.
* 数据与Xenacoelomorpha属的单相一致.
*这项研究提供了支持Xenambulacrarian假设Xenacoelomorpha的遗传学位置的证据.

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