区分良性和恶性甲状腺结节使用血三甲基胺N-氧化物,卡尼丁,胆和贝他因
Liang Shi1, Muhong Guo2, Cuixiao Shi1
1Department of Nuclear Medicine, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China.
Journal of cancer research and clinical oncology
|March 20, 2024
概括
三甲基胺N氧化物 (TMAO) 和其前体显示出作为甲状腺结节的诊断生物标志物的潜力. 增加的TMAO和减少的前体可能有助于区分良性和恶性甲状腺疾病.
科学领域:
- 代谢学 代谢学 代谢学
- 肠道微生物组研究研究
- 甲状腺癌的诊断 甲状腺癌的诊断
背景情况:
- 肠道微生物组衍生的代谢物,如三甲基胺N氧化物 (TMAO) 和它们的前体 (碳素,胆,贝) 越来越多地被认为在各种健康状况中的作用.
- TMAO及其前体与甲状腺癌 (TC) 风险之间的特定关联,以及它们对甲状腺结节的诊断实用性,仍未得到充分研究.
研究的目的:
- 调查血三甲基胺N氧化物 (TMAO) 和其前体 (碳素,胆,贝他因) 的诊断价值,以区分良性甲状腺结节 (BTN) 和恶性甲状腺结节 (TC).
- 评估这些代谢物的潜力,作为用于甲状腺结节诊断的新生物标志物.
主要方法:
- 在215名TC患者,63名BTN患者和148名健康对照者 (HC) 中,使用高性能液体染色学-并联质谱法量化TMAO,胆,卡尼丁和贝他因的血水平.
- 进行了统计比较 (克鲁斯卡尔-瓦利斯测试),以分析代谢物跨组的分布.
- 用接收器操作特征 (ROC) 曲线分析来评估单个和组合代谢物的诊断性能.
主要成果:
- 与健康对照组 (HC) 相比,甲状腺癌 (TC) 患者的TMAO水平显著提高,卡尼丁,胆和贝他因水平降低 (P < 0.001).
- 与HC相比,良性甲状腺结节 (BTN) 显示血胆 (P < 0.01) 和贝他因 (P < 0.05) 降低,与TC患者相比,甲状腺胆 (P < 0.001) 和胆 (P < 0.05) 水平显著上升.
- 对四种代谢物的综合分析表明在差异诊断中表现良好,TC与HC的ROC曲线下的面积为0.793,BTN与HC的面积为0.741,TC与BTN的面积为0.703.
结论:
- 血TMAO及其前体显示出作为新生物标志物的潜力,用于对良性和恶性甲状腺结节的差异诊断.
- 这些代谢物的综合分析在区分不同类型的甲状腺结节和健康个体方面提供了有希望的准确性.
相关概念视频
Hyperthyroidism I: Introduction
Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
Hyperthyroidism II: Pathophysiology
Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
Goiter
Goiter refers to an abnormal enlargement of the thyroid gland that may appear as a diffuse goiter (uniform enlargement) or nodular (single or multiple nodules). Functionally, it is classified as nontoxic (normal/low hormone levels) or toxic (excess hormone production).PathophysiologyDiffuse thyroid enlargement typically results from prolonged stimulation by thyroid-stimulating hormone (TSH) or TSH-like agents, commonly seen in hypothyroidism or iodine deficiency. In contrast, in hyperthyroid...


