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在瘤血管生长抑制方面的进展

Keyong Zhang¹, Yuanyuan Shi¹, Ze Jin¹

¹State Key Laboratory of Targeting Oncology, National Center for International Research of Bio-Targeting Theranostics, Guangxi Key Laboratory of Bio-Targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Medical University, Nanning, 530021, Guangxi, China.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

|March 20, 2024

概括

瘤生长和转移依赖于新的血管形成. 本综述涵盖了抗血管性疗法,从传统药物到先进的免疫疗法和纳米材料,用于抗瘤治疗.

科学领域:

在瘤学瘤学.
血管生物学血管生物学
药物开发药物开发

背景情况:

瘤生长和转移需要新血管化,这个过程受到瘤微环境因素的影响,如缺氧和酸度.
瘤微环境破坏了血管生成因子平衡,导致血管异质,推动了瘤的进展和转移.
抑制瘤血管生成是抗瘤疗法的关键策略.

研究的目的:

审查瘤血管生成的机制.
总结当前的抗血管生成药物及其治疗进展和挑战.
概述先进的抗血管生成策略,包括免疫疗法和纳米材料.

主要方法:

关于瘤血管生成机制的科学文献的综述.
对现有的抗血管原药 (单克隆抗体,小分子抑制剂) 的分析.
探索新兴的抗血管生成策略 (免疫疗法,纳米材料).

主要成果:

瘤血管生成是一个复杂的过程,涉及多个因素,受瘤微环境的影响.
传统的抗血管性药物向特定的途径,但在有效性和耐药性方面面临挑战.
像免疫疗法和纳米材料这样的先进策略为抗血管生成疗法提供了新的途径.

结论:

了解瘤血管生成机制对于开发有效的抗癌治疗至关重要.
目前的抗血管生成疗法显示出有前途,但需要进一步优化以克服局限性.
抗血管生成疗法的未来方向包括整合免疫疗法和纳米技术,以提高抗瘤疗效.

关键词:

抗血管性疗法是一种抗血管性疗法.组合疗法是一种联合疗法.免疫治疗是一种免疫疗法.纳米材料是一种纳米材料.新血管化的新血管化.瘤是一个瘤.

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