使用猪细胞外基质重建整个中枢门:添加一个环Annuloplasty.
Johannes H Jedrzejczyk1,2, Stine Krog3,4, Søren N Skov3,4
1Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200, Århus, Denmark. johjed@clin.au.dk.
Cardiovascular engineering and technology
|March 20, 2024
概括
使用CorMatrix®添加灵活的结婚整形环来重建中膜,改变了膜的形状,导致吐. 研究人员不建议这种组合,建议进一步调查合适的结婚整形器件.
科学领域:
- 生物材料科学 生物材料科学
- 心血管外科心血管外科
- 医疗器械 医疗器械
背景情况:
- 密特拉重建在恢复生理功能方面存在挑战.
- 细胞外矩阵 (ECM) 移植,如CorMatrix®,提供了门修复的潜力.
- 造环的目的是在心脏循环期间稳定门.
研究的目的:
- 在猪模型中,通过CorMatrix®移植进行重建后,研究灵活的结婚整形环对中枢的几何和动态的影响.
- 为了评估Simulus®柔性环与CorMatrix®中枢重建的兼容性.
主要方法:
- 具有自我控制设计的急性猪模型 (n=8).
- 使用双层小肠子下粘膜ECM (CorMatrix®) 管移植进行完整的 mitra 重建.
- 在重建后插入Simulus®柔性结婚整形环.
- 通过声微观测和心声回声学进行表征,重点关注环状几何和膜动力学.
主要成果:
- 与单独的重建相比,化环插入保持了更稳定的平面环状动力学.
- 在戒指插入后,通道-通道距离显著减少 (35.0±3.4毫米 vs 27.4±1.9毫米,P<0.001).
- 从生理 D 形转变为圆形环状,导致叶片合并和中央吐喷气.
结论:
- 通过使用CorMatrix®结合灵活的结婚整形术,成功地实现了对关节的重建.
- 环形整形减少了非生理学缩扩大,但改变了环形形状.
- 由于不良的叶片吸收和反,不建议与此技术一起使用Simulus柔性环;需要进一步研究合适的取消整形术.
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