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Updated: Jun 30, 2025

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胰岛素信号通过调节AMPK活性来调节Pink1mRNA定位,以支持神经元中的PINK1功能

J Tabitha Hees1,2, Simone Wanderoy1,2, Jana Lindner2

  • 1TUM Medical Graduate Center, Technical University of Munich, Munich, Germany.

Nature metabolism
|March 20, 2024
PubMed
概括

胰岛素信号阻止Pink1mRNA与线粒体结合,这对于PINK1激活和线粒细胞衰变至关重要. 这种代谢控制在阿尔茨海默氏症中被破坏.

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