特里戈内林是一种NAD+前体,在衰老过程中改善肌肉功能,在人类肉症中减少
Mathieu Membrez1, Eugenia Migliavacca1, Stefan Christen2
1Nestlé Institute of Health Sciences, Nestlé Research, Lausanne, Switzerland.
Nature metabolism
|March 20, 2024
概括
作为一种天然化合物,trigonelline可以提高尼古丁胺胺氨基二核酸 (NAD+) 的水平,从而改善肌肉健康和衰老中的功能. 补充剂显示了与年龄相关的肌肉衰退的治疗潜力.
科学领域:
- 老年学是一门学科.
- 线粒体生物学 线粒体生物学
- 营养科学 营养科学
背景情况:
- 线粒体功能障碍和尼古丁胺胺二核酸 (NAD+) 低水平与骨肌肉衰老和肉症有关.
- 这些缺陷的起源 (局部与系统/饮食) 仍然不清楚.
研究的目的:
- 为了研究循环中的三角蛋白,NAD+水平和跨物种的肌肉健康之间的功能联系.
- 探索三素作为一种潜在的NAD+增强策略,用于与年龄相关的肌肉衰退.
主要方法:
- 人体血清中的三氨酸水平与肉症,肌肉强度和线粒体功能相关.
- 用天然和标记形式评估了trigonelline对NAD+水平的影响在Caenorhabditis elegans,小鼠和人类肌管中.
- 机制研究包括评估GPR109A激活和尼古丁酸基转移酶/普雷斯-汉德勒通路.
- 评估了C. elegans (线粒体呼吸,肌肉消耗,寿命,移动性) 和小鼠 (肌肉强度,疲劳) 的功能结果.
主要成果:
- 人体血清中的三角氨酸水平随着肉症而降低,并且与肌肉强度和线粒体氧化酸化正相关.
- 特里戈内林补充剂在C. elegans,小鼠和人类髓管中增加了NAD+水平.
- 在C. elegans中,三增强了线粒体功能,减少了肌肉消耗,并通过依赖NAD+的,需要Sirtuin的途径延长了寿命和移动性.
- 在小鼠中,饮食中补充三氨酸可改善肌肉强度,并预防与年龄相关的疲劳.
结论:
- 特里戈内林是NAD+池的功能成分,影响肌肉健康.
- 特里戈内林补充剂是一种可行的NAD+增强策略,具有治疗萨尔科佩尼亚和与年龄相关的肌肉衰退的治疗潜力.
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