益生菌通过调节炎症途径改善内分泌疾病:系统性审查
Marzieh Nemati1, Bahareh Ebrahimi2, Nima Montazeri-Najafabady3,4
1Endocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Genes & nutrition
|March 20, 2024
概括
益生菌有望通过调节免疫反应和炎症通路来控制肥胖和糖尿病等内分泌疾病. 这次审查强调了乳杆菌菌株在减少促炎性细胞因子方面特别有效.
科学领域:
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
背景情况:
- 益生菌为包括肥胖,糖尿病和代谢综合征在内的内分泌疾病提供了潜在的治疗策略.
- 益生菌对内分泌健康的确切作用机制仍在研究中,免疫系统调节是关键假设.
研究的目的:
- 系统地审查各种益生菌菌株在治疗内分泌疾病方面的疗效证据.
- 研究益生菌在调节炎症途径中的作用,包括促炎和抗炎细胞因子.
主要方法:
- 在PubMed和Scopus进行了系统的文献搜索,包括人类和动物研究.
- 在独立质量评估后,从超过15,000篇最初识别的论文中选择了25项符合条件的研究.
- 提取了益生菌菌株,内分泌条件和免疫调节效应的数据.
主要成果:
- 乳酸菌成为最常用的益生菌,显示出显著的治疗效果,特别是在通过免疫反应调节来控制肥胖症.
- 发现益生菌通过抑制促炎途径来改善内分泌疾病,特别是降低肥胖患者的瘤坏死因子-α (TNF-α) 水平和糖尿病患者的干白素-6 (IL-6) 水平.
- 对炎症性细胞因子和其他免疫因子的调节在所有研究中都得到了一致的观察.
结论:
- 益生菌可以通过其免疫调节特性有效地管理内分泌疾病.
- 针对炎症途径,特别是通过减少TNF-α和IL-6等促炎细胞因子,是益生菌益处的关键机制.
- 对特定益生菌菌株及其精确机制的进一步研究是有必要的,以优化治疗应用.
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