怀孕期间暴露于抗生素会增加患儿期亚托皮性疾病的风险:一项全国性的队列研究
Sheng-Kang Tai1, Yi-Hsuan Lin2,3,4, Ching-Heng Lin5
1Department of Pediatrics, Show Chwan Memorial Hospital, Changhua, Taiwan.
European journal of medical research
|March 20, 2024
概括
产前抗生素暴露与儿童疹和喘等形疾病的风险增加有关. 这种关联似乎取决于剂量,这表明更多的暴露会导致更高的风险.
科学领域:
- 流行病学 流行病学
- 儿科 儿科 儿科
- 免疫学 免疫学 免疫学
背景情况:
- 无形性疾病,包括喘,过敏性鼻炎和无形性皮肤炎,患病率有所上升.
- 之前的研究表明,怀孕期间使用抗生素和儿童发展亚托皮性疾病之间存在潜在的联系.
研究的目的:
- 调查产前抗生素暴露与儿童亚托皮性疾病发生率之间的关联.
- 对这种关系进行全国范围的基于人口的分析.
主要方法:
- 一项基于全国人口的队列研究,利用台湾国家健康保险研究数据库.
- 包括2004-2010年第一次怀孕,儿童至少需要5年的随访.
- 根据门诊诊所访问或住院诊断的诊断代码来定义阿托皮性疾病.
主要成果:
- 总共有900,584名儿童被纳入分析.
- 对亚托皮性皮炎,喘和过敏性鼻炎的调整后危险比分分别为1.12,1.06和1.08,所有这些都具有统计学意义.
- 一个趋势表明,产前抗生素暴露与儿童亚托皮性疾病风险之间存在剂量依赖的关系.
结论:
- 产前接触抗生素可能会增加儿童患亚托皮性疾病的风险.
- 观察到的风险增加似乎取决于剂量,更高的暴露与更高的风险相关.
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