来自微生物群的英多尔可以缓解肠道炎症,并通过微生物交叉养来调节微生物群
Gang Wang1,2,3, Yuxin Fan1,2, Guolong Zhang4
1State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China.
由Lactobacillus产生的英多尔-3-乳酸 (ILA) 通过促进有益的英多尔衍生物来对抗肠道炎症和失生症. 这一发现为肠道健康提供了潜在的新"后生物"治疗方法.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 代谢学 代谢学 代谢学
背景情况:
- 主体微生物群的相互作用对于恒温和疾病易感性至关重要.
- 微生物托代谢物显著影响宿主生理学.
- 这些代谢物在微生物间交流中的作用在很大程度上是未知的.
研究的目的:
- 研究微生物托代谢物在宿主微生物群相互作用和微生物间交流中的作用.
- 确定参与维持肠道平衡的关键分子.
- 探索这些代谢物的潜在治疗应用.
主要方法:
- 研究了由Lactobacillus生产的英多尔-3-乳酸 (ILA) 的功能.
- 在小鼠中使用了DSS诱导和IL-10-/-结肠炎模型.
- 分析了细菌酶表达和代谢物产生 in vitro 和 in vivo.
- 野生型乳酸菌与缺乏ILA生产的突变菌株进行了比较.
主要成果:
- 乳酸菌会将酸盐代谢成ILA,这可以防止肠道炎症和失生症.
- ILA,英多尔-3-酸 (IPA) 和英多尔-3-酸 (IAA) 减轻炎症并调节肠道微生物群.
- ILA通过微生物交叉养增强了其他醇衍生物的产生,特别是在失生症期间.
- 一种缺乏 ILA 的 Lactobacillus 突变体未能对炎症进行保护.
结论:
- 微生物群衍生的醇调解微生物间的通信,有助于肠道平衡.
- 这些发现表明,潜在的治疗策略是使用微生物群衍生代谢物或"后生物"来治疗因失生症引起的疾病.
更多相关视频
07:15An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
Published on: July 31, 2019
08:24Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach
Published on: May 2, 2018
相关概念视频
Irritable Bowel Syndrome I: Introduction
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Bacterial Flora of the Large Intestine
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...
Anatomy of the Intestines
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
