目前对诺西普拉斯痛的理解
Yeong-Min Yoo1, Kyung-Hoon Kim1
1Department of Anesthesia and Pain Medicine, School of Medicine, Pusan National University, Yangsan, Korea.
The Korean journal of pain
|March 20, 2024
概括
无囊性疼痛涉及改变疼痛处理而没有明显的组织损伤,通常与中央敏感性有关. 了解这种机制是诊断和管理慢性疼痛疾病的关键.
科学领域:
- 疼痛研究 疼痛研究
- 神经科学是一个神经科学.
- 临床疼痛管理 临床疼痛管理
背景情况:
- 国际疼痛研究协会 (International Association for the Study of Pain) 定义说,诺西普拉斯疼痛是由于改变的感觉而产生的疼痛,而没有明显的感觉或神经病痛的证据.
- 提升中枢神经系统疼痛处理和改变疼痛调节是提出的机制.
- 它包括慢性区域性疼痛,引起的疼痛过敏性 (Allodynia),并经常包括疲劳和睡眠障碍等并发症.
研究的目的:
- 为了定义nociplastic疼痛及其拟议的机制.
- 概述识别可能和可能的诺西普拉斯痛的临床标准.
- 为了探讨囊性疼痛,中央敏感化和各种慢性疼痛障碍之间的关系.
主要方法:
- 审查和综合的定义和建议的机制的nociplastic疼痛.
- 对诺西普拉斯疼痛的临床标准的分析,包括过敏和并发症.
- 识别与中央敏感相关的相关疾病.
主要成果:
- 诺西普拉斯疼痛的特点是改变了 nociception 和中心敏感化.
- 临床标准从可能 (区域性疼痛,过敏) 发展到可能 (广泛的过敏,并发症).
- 相关疾病包括纤维肌痛,慢性疲劳综合征,易怒肠综合征和头痛等.
结论:
- 诺基普拉斯疼痛代表了由中央敏感性驱动的慢性疼痛的一个重要类别.
- 它整合了感官和情感组成部分,超越了传统的感觉或神经病痛疼痛分类.
- 需要进一步的标准来确定绝对的nociplastic疼痛,但目前的理解有助于解释无法解释的慢性疼痛.
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