查确诊的乳病儿童的维生素和矿物质状况:一个病例控制研究
Abdulrahman Al-Hussaini1,2,3, Riccardo Troncone4, Suzan Alobaid5
1Division of Pediatric Gastroenterology, Children's Specialized Hospital, King Fahad Medical City, Riyadh, Saudi Arabia.
Journal of pediatric gastroenterology and nutrition
|March 20, 2024
概括
在儿童中早期诊断乳病 (CeD) 仍然显示出微量营养素缺乏. 在早期诊断的CeD患者中,对这些缺陷的常规查具有临床价值.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 营养科学 营养科学
- 结核病研究 结核病研究
背景情况:
- 经典的乳病 (CeD) 诊断通常与微量营养素缺乏有关.
- 通过查进行早期诊断可能会改变CeD及其相关缺陷的表现.
研究的目的:
- 确定早期诊断,查识别的CeD的儿童中微量营养素缺乏的患病率.
- 在这个儿科群体中评估常规微量营养素测试的临床实用性.
主要方法:
- 一项病例控制研究涉及84名患有查确定的CeD的儿童和443名对照.
- 测量血红蛋白,铁,铁素,叶酸,维生素B12,维生素A,维生素E,25-OH维生素D,,铜和的水平.
主要成果:
- 与对照人群相比,患有早期诊断的CeD儿童的血红蛋白,铁,铁素,维生素D,,铜和水平显著降低.
- 患有严重肠损伤 (Marsh IIIb-IIIc) 的患者的血清费里和维生素A水平低于轻度损伤 (Marsh II-IIIa) 的患者.
结论:
- 微量营养素缺乏甚至存在于早期诊断,查识别的乳病病例中.
- 这些发现支持了对CeD的查和早期诊断的临床相关性.
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