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Updated: Jun 30, 2025

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Diagonal Method to Measure Synergy Among Any Number of Drugs
Published on: June 21, 2018
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临床相关的草药相互作用:一个30年的历史评估
1National Center for Natural Products Research, School of Pharmacy, University of MS, University, MS, USA.
Journal of dietary supplements
|March 20, 2024
概括
植物性食补充剂 (BDS) 在过去30年里显著增长. 本综述详细介绍了BDS引起的临床相关的草药相互作用 (HDI),探讨了它们的药理动力学和药理动力学机制.
科学领域:
- 药理学 药理学 是一个学科.
- 自然产品 化学 化学
- 综合医学是一个整体的医学.
背景情况:
- 2024年10月的食补充剂健康和教育法案 (DSHEA) 周年纪念日标志着食补充剂进化的30年.
- 食补充剂的使用量急剧增加,植物食补充剂 (BDS) 成为快速增长的市场部分.
- BDS是复杂的植物化学物质混合物,通常与常规处方药一起摄入.
研究的目的:
- 审查过去30年中发现的植物性食补充剂 (BDS).
- 总结那些具有临床意义的草药相互作用 (HDI) 的 BDS.
- 阐明这些HDI背后的药理动力学和药理动力学机制.
主要方法:
- 关于BDS及其与处方药物的相互作用的文献综述.
- 确定临床意义上的草药相互作用 (HDI).
- 将HDI机制分类为药理动力学和药理动力学途径.
主要成果:
- 30多年来,食补充剂产品的数量急剧增加,BDS显示出显著的市场增长.
- 植物性食补充剂 (BDS) 经常与处方药相互作用,导致临床上显著的草药相互作用 (HDI).
- 已识别的HDI机制包括药物受体水平上的药理学相互作用和涉及药物代谢酶和载体的药理学相互作用.
结论:
- 植物性食补充剂 (BDS) 是药物治疗的一个复杂领域,原因是潜在的草药相互作用 (HDI).
- 了解HDI的药理动力学和药理动力学机制对于患者的安全至关重要.
- 本次审查强调了与越来越多的BDS使用相关的HDI识别和管理的重要性.
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