怀孕期间接触大麻和围产期结果:一个队列研究
Maia Brik1, Miguel Sandonis2,3, Alina Hernández-Fleury1
1Obstetrics Department, Maternal-Fetal Medicine Unit, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
Acta obstetricia et gynecologica Scandinavica
|March 20, 2024
概括
产前大麻使用与不良的产周结局有关,如低出生体重和早产. 然而,在对其他药物使用和停药进行控制后,与妊娠年龄 (SGA) 出生小的相关性并不显著.
科学领域:
- 围产期健康 围产期健康
- 生殖毒理学 生殖毒理学
- 产科 产科 产科 产科 产科
背景情况:
- 在怀孕期间使用大麻的流行率越来越高.
- 需要了解产前大麻对胎儿发育和围产期结果的影响.
研究的目的:
- 调查产前大麻使用与胎儿生长,早产和其他围产问题之间的关联.
- 通过控制混因素来澄清影响.
主要方法:
- 在第三级护理中心对单子妊娠的倾向性得分匹配分析.
- 基于大麻检测测试的女性纳入.
- 主要结局:对于妊娠年龄来说小 (SGA),低出生体重,早产.
- 二次结局:新生儿生物识别,呼吸困难,新生儿重症监护室入院,母乳养.
- 第二次分析排除了其他药物使用和大麻戒断.
主要成果:
- 产前大麻使用与SGA,低出生体重,早产,NICU入院和呼吸困难的几率增加有关.
- 观察到出院时母乳养率较低.
- 在排除混因素后,产前大麻和SGA之间的关联并不显著.
结论:
- 产前大麻使用与不良的产周结局有关,包括SGA,低出生体重和早产.
- 当排除其他药物使用和停药等混因素时,与SGA的联系就会减少.
- 需要进一步的研究,以充分阐明与产前大麻暴露相关的风险.
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