在视网膜色素炎中使用骨髓衍生中酶体干细胞疗法
Nil Irem Ucgun1, Cenk Zeki Fikret2, Mualla Sahin Hamurcu1
1Department of Ophthalmology, University of Health Sciences, Ankara City Hospital, Ankara, Turkey.
Current stem cell research & therapy
|March 20, 2024
概括
介质细胞干细胞治疗改善了视网膜炎色素患者的视力. 骨髓衍生干细胞的深部下注射增强了视觉敏度和视野,没有观察到任何不良影响.
科学领域:
- 眼科医生 眼科 眼科
- 再生医学是一种再生医学.
- 干细胞疗法 干细胞疗法
背景情况:
- 视网膜色素炎是一种渐进的遗传性疾病,导致严重的视力丧失.
- 目前对视网膜色素炎的治疗方法有限.
研究的目的:
- 为了评估骨髓衍生中介细胞干细胞治疗视网膜色素炎的疗效.
- 评估干细胞治疗对视觉敏度和视野的影响.
主要方法:
- 27名患有视网膜色素炎的患者接受了来自骨髓的异性骨髓基质干细胞的深注射.
- 眼科检查,OCT,视野测试,VEP和ERG在治疗前和治疗后1,3个月和6个月进行.
主要成果:
- 在视觉敏度 (logMAR),视野 (dB) 和质细胞层厚度 (微米) 中观察到有统计学意义的改善.
- 在治疗后,VEP幅度和ERG延迟的显著改善.
- 视敏度为p < 0.001,视野为p = 0.005,细胞层为p = 0.003,VEP为p = 0.013 ,ERG为p = 0.02.
结论:
- 骨髓衍生性介质干细胞疗法对视网膜色素炎患者的视觉功能产生了积极的影响.
- 在这种情况下,深部子注射是干细胞治疗的可行的注射途径.
- 在6个月的随访期间,没有报告系统性或眼科副作用.
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