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帕拉莫利德A-E的总合成

Yu Zhang1, Lijun Chen1, Yanxing Jia1

  • 1State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, and Chemical Biology Center, Peking University, 38 Xueyuan Road, Beijing, 100191, P. R. China.

Angewandte Chemie (International ed. in English)
|March 20, 2024
PubMed
概括

研究人员报告了第一个pallamolides A-E.E.的总合成. 这项研究详细介绍了新的化学转换来构建复杂的四环结构,推进有机合成方法.

关键词:
迪特尔佩诺类动物 (Diterpenoids) 是一种形类动物.自然产品是天然产品.减少循环的循环化连续的迈克尔补充.总的合成总的合成.

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相关概念视频

Preparation of Diols and Pinacol Rearrangement01:57

Preparation of Diols and Pinacol Rearrangement

Compounds bearing two hydroxyl groups are known as diols. When the hydroxyl groups are located on adjacent carbon atoms, the diols are called vicinal diols or glycols. Under acidic conditions, vicinal diols undergo a specific reaction called pinacol rearrangement.
The reaction begins with transferring a proton from the acid catalyst to one of the hydroxyl groups, producing an oxonium ion.