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Updated: Jun 30, 2025

Characterization of pH-Dependent Reversible Self-Assembly of Amyloid Beta 1-40-Coated Gold Colloids
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Characterization of pH-Dependent Reversible Self-Assembly of Amyloid Beta 1-40-Coated Gold Colloids

Published on: March 21, 2025

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氨基酸β纤维组合动力学的pH依赖性:解开微观分子过程

Yao Tian1, John H Viles1

  • 1Department of Biochemistry School of Biological and Behavioural Sciences Queen Mary University of London London UK.

Angewandte Chemie (Weinheim an der Bergstrasse, Germany)
|March 20, 2024
PubMed
概括

阿尔茨海默氏病的研究表明,pH影响粉样β (Aβ) 纤维素的形成. 初级核化是pH依赖的,而二次核化和延长不是,为有毒Aβ组装提供了洞察力.

关键词:
阿尔茨海默病 阿尔茨海默病粉样蛋白是什么 粉样蛋白是什么绝缘电点 是一个绝缘电点.运动学 运动学分子机制分子机制

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
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