染色选择性光催化使立体补充生物催化途径成为可能
Luca Schmermund1, Susanne Reischauer2, Sarah Bierbaumer1
1Institute of Chemistry Department of Organic and Bioorganic Chemistry University of Graz, NAWI Graz, BioTechMed Graz Heinrichstrasse 28 8010 Graz Austria.
Angewandte Chemie (Weinheim an der Bergstrasse, Germany)
|March 20, 2024
概括
这项研究证明了使用碳化物 (CN-OA-m) 调整氧化还原潜力的波长控制光催化. 这使得 (S) -或 (R) -乙醇反体通过光化学酶级联能够被选择性合成.
科学领域:
- 化学工程是化学工程的重要组成部分.
- 光催化作用的光催化
- 酶催化酶的催化作用
背景情况:
- 控制化学反应选择性与外部刺激是在热过程中建立的,但在可见光光催化中具有挑战性.
- 可见光光催化剂为化学合成提供了一种可持续的替代方案,但实现高反选择性仍然是一个重大障碍.
研究的目的:
- 为了证明碳化物光催化剂 (CN-OA-m) 的波长调节的氧化还原潜力,以控制化学反应选择性.
- 开发用于乙醇异构体的选合成的光化学酶级联.
主要方法:
- 通过调整辐射波长 (绿光与蓝光) 来调整CN-OA-m的氧化还原潜力.
- 使用来自 *Agrocybe aegerita* 的非特异性过氧酶进行反选择性基化.
- 使用来自 * Rhodococcus ruber * 的酒精脱酶进行 enantioselective 减少.
主要成果:
- 绿光照射CN-OA-m促进了乙基到 (R) -1-乙醇的异选择性氧化,其中99%的异过量 (ee).
- 蓝光照射CN-OA-m导致乙基的光催化氧化为乙烯酸,随后进行了对 (S) -1-乙醇的酶选择性降解,效果为93% ee.
结论:
- 可见光光催化剂可以通过波长来控制,以在化学合成中实现高的反选择性.
- 开发的光化学酶级联策略提供了一个多功能平台,用于生产有价值的性化合物的特定反体.
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