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Updated: Jun 30, 2025

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors
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Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors

Published on: July 17, 2020

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固体瘤中的氨酸酸酶PTPN11/SHP2 - 针对性治疗的牛眼?

Xun Chen1,2, Steffen Johannes Keller1, Philipp Hafner1

  • 1Department of General and Visceral Surgery, Center for Surgery, Medical Center University of Freiburg, Freiburg, Germany.

Frontiers in immunology
|March 20, 2024
PubMed
概括

含有Src-homology 2域的酸酶2 (SHP2) 在癌症中起着双重作用,促进固体瘤的生长,但很少发生突变. 用抑制剂向SHP2显示出癌症治疗的前景.

关键词:
在 SHP2 中, SHP2 是 SHP2.免疫微观环境 免疫微环境信号通道的信号通道.固体瘤是一个固体瘤.治疗耐药性 治疗耐药性瘤微环境是一个微环境.

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