胸外转移的非小细胞肺癌的最佳治疗策略:基于SEER数据库的研究
Zhehao He1, Xuqi Sun2, Jinming Xu1
1Department of Thoracic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Journal of thoracic disease
|March 20, 2024
概括
手术可以有利于非小细胞肺癌 (NSCLC) 患者单次胸外转移 (EM). 建议进行切除术以改善存活率,即使对于较小的原发性瘤.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 癌症研究 癌症研究
背景情况:
- 具有胸外转移 (EM) 的非小细胞肺癌 (NSCLC) 呈现出一个异质的患者群体.
- 确定初级瘤手术的候选人对于优化治疗策略至关重要.
研究的目的:
- 为了确定可能从初级瘤切除中受益的NSCLC患者.
- 为了确定这个患者队列的最佳治疗策略.
主要方法:
- 利用监测,流行病学和最终结果数据库 (2010-2015年) 对患有EM的NSCLC患者.
- 将患者分层分为单组和多组EM子组.
- 采用考克斯回归和卡普兰-梅尔分析来评估预后因素并比较生存结果.
主要成果:
- 多变量分析确定了EM的数量和治疗方式作为整体存活时间 (OS) 的独立预后因素.
- 与单一EM患者的单一疗法相比,组合疗法显著改善了OS.
- 脑膜切除术,双眼切除术或肺切除术导致明显更长的存活时间比单次EM的亚叶切除,无论主要瘤的大小 (≤2厘米).
结论:
- 初级瘤手术为单次EM的NSCLC患者提供了生存益处.
- 乳房切除术是一种合理的外科手术方法,以提高生存率,即使在初级瘤≤2厘米的情况下也是如此.
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