增加的BMI和认知功能之间的关联在第一期药物原始的男性精神分裂症中
Xing Deng1, Shuiping Lu1, Yan Li1
1Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.
Frontiers in psychiatry
|March 20, 2024
概括
超重和肥胖是常见的第一期药物素朴精神分裂症患者. 较高的身体质量指数 (BMI) 与这些人工作记忆和视觉学习的恶化有关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 肥胖对精神分裂症的不良影响是众所周知的,但对其对初始,未经治疗的疾病的影响知之甚少.
- 第一次药物原始性精神分裂症 (FEDN) 是研究早期疾病机制的关键窗口.
研究的目的:
- 研究FEDN精神分裂症患者体质指数 (BMI) 和认知功能之间的关系.
- 为了确定超重或肥胖是否加剧早期精神分裂症的认知缺陷.
主要方法:
- 143名FEDN精神分裂症患者的BMI,血糖和脂质水平进行了评估.
- 认知功能使用 MATRICS 共识认知电池 (MCCB) 进行评估.
- 使用相关性和回归分析来检查BMI与认知表现的关系.
主要成果:
- 在FEDN精神分裂症队列中,超重和肥胖的患病率为33.57%.
- 与正常/体重不足患者相比,超重/肥胖患者在工作记忆和视觉学习方面表现出更严重的损伤.
- 较高的BMI与工作记忆和视觉学习负相关,BMI预测工作记忆下降.
结论:
- 在FEDN精神分裂症患者中,很大一部分患者超重或肥胖.
- 体重指数与认知功能有关,特别是在早期精神分裂症中影响工作记忆.
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