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早期生活逆境对精神分裂症患者社会认知功能的独立影响
Xing Peng1,2,3, Wen-Peng Hou2,3, Yu-Shen Ding2,3
1School of Public Health, North China University of Science and Technology, Tangshan, China.
Frontiers in psychiatry
|March 20, 2024
概括
早期的生活逆境,包括童年创伤和欺凌,在精神分裂症患者中显著损害认知功能,特别是社会认知 (SC). 这些不良体验与精神分裂症患者更严重的认知缺陷有关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 心理学 心理学 心理学
背景情况:
- 精神分裂症与认知缺陷有关,影响日常功能.
- 早期的生活逆境 (ELA) 是精神分裂症病理生理学和症状严重性的潜在因素.
- 社会认知 (SC) 特别容易受到精神分裂症认知障碍的影响.
研究的目的:
- 研究ELA对精神分裂症患者认知功能的影响.
- 专门研究精神分裂症中ELA和社会认知 (SC) 之间的关系.
- 为了比较精神分裂症患者与没有童年创伤史的认知功能.
主要方法:
- 招募了三个组:患有童年创伤的精神分裂症 (SCZ-ct),没有童年创伤的精神分裂症 (SCZ-nct) 和健康的对照组 (HC-nct).
- 使用韦克斯勒缩短情报量表 (WAIS-RC) 评估情报.
- 使用 MATRICS 共识认知电池 (MCCB) 和 ELA 评估认知功能,使用童年创伤问卷-简单表格 (CTQ) 和成人欺凌量表 (BSA).
主要成果:
- 精神分裂症患者报告CTQ和BSA得分明显高于对照组.
- 在MCCB总分和SC域中,SCZ-ct组表现出最明显的认知障碍.
- 儿童创伤 (CTQ) 和欺凌 (BSA) 分别与认知功能 (MCCB) 和SC负相关.
结论:
- 包括家族创伤和欺凌在内的ELA在精神分裂症患者中很普遍.
- 这些不良经历显著导致精神分裂症患者的社会认知 (SC) 严重受损.
- 针对ELA的干预措施可能对改善精神分裂症的认知结果至关重要.
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