黎巴嫩COVID-19患者中血栓形成的几率和相关因素:一个病例对照回顾性研究
Mahmoud Youness1, Sara Mansour2, Fouad Sakr2
1Research Department, Beirut Cardiac Institute, Beirut, Lebanon.
Journal of pharmaceutical policy and practice
|March 20, 2024
概括
COVID-19患者面临着血栓形成的显著风险,以前的事件和抗高血压药物的使用增加了几率. 在住院和不严重的疾病期间使用抗凝剂可以降低这种风险.
科学领域:
- 医学研究 医学研究
- 传染性疾病 传染性疾病
- 心血管血栓形成的原因是心血管血栓.
背景情况:
- 血栓栓塞栓症发生在高达27%的COVID-19患者中.
- 系统性炎症和患者特异性因素导致SARS-CoV-2感染中的血栓形成.
研究的目的:
- 为了确定黎巴嫩COVID-19患者血栓形成的几率.
- 为了确定与这一群体中血栓形成相关的因素.
主要方法:
- 追溯病例控制研究 (2021年1月至5月).
- 病例:COVID-19患者有血栓形成;对照:COVID-19患者没有血栓形成.
- 通过社会人口统计,临床参数和疾病严重程度的调查问卷收集的数据.
主要成果:
- 在267名患者中,9.7%患有血栓形成;心肌梗塞是最常见的 (34.6%).
- 之前发生的血栓栓塞事件 (OR=9.160) 和使用抗高血压药物 (OR=3.116) 观察到血栓形成风险增加.
- 与女性性别相关的风险降低 (OR=0.330),抗凝剂使用 (OR=0.126),以及不严重的COVID-19 (OR=0.273).
结论:
- 患有血栓栓塞的COVID-19患者面临更高的死亡风险.
- 抗凝固药治疗显著降低了COVID-19患者血栓栓塞的风险.
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