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Updated: Jun 30, 2025

Author Spotlight: Characterizing DNA G-Quadruplex by Bis-3-Chloropiperidine Based Chemical Mapping
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通过对异芳香的支架和侧链进行结构调整来选择性地识别G-Quadruplex

Khushnood Fatma1, Prasanth Thumpati1,2, Deepanjan Panda1

  • 1Indian Association for the Cultivation of Science, 2A & 2B, Raja Subodh Chandra Mallick Road, Jadavpur, Kolkata-700032, India.

ACS medicinal chemistry letters
|March 20, 2024
PubMed
概括

一种新型的碳醇衍生物MC-4在癌细胞中选择性地准并稳定c-KIT 1 G-四重复 (G4). 这种G4连接体减少了c-KIT基因表达,诱导了细胞亡,并显示了治疗潜力.

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