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Updated: Jun 30, 2025

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

Published on: August 16, 2018

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新型GABAB PAMs:根据蛋白质结构的角度来看,结构-活性关系

Balázs Krámos1, Zsuzsa Hadady2, Attila Makó2

  • 1Spectroscopic Research Department, Gedeon Richter Plc., Gyömrői út 19-21, Budapest, 1103 Hungary.

ACS medicinal chemistry letters
|March 20, 2024
PubMed
概括

研究人员优化了一个pyrazolo[1,5-a]pyrimidine化合物,以增强GABA B受体的效能. 该研究发现了一种新型的碳酸特性,对于改善候选药物特性和结合相互作用至关重要.

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