复杂的基因组重新排列模式在恶性多层甲状腺瘤由于环境石棉暴露

Tunç Tuncel1, Güntülü Ak2, Hasan Veysi Güneş3

  • 1Health Institutes of Turkey, Turkish Biotechnology Institute, Ankara, Turkey.

概括

恶性多叶层层层瘤 (MPM) 的基因组分析揭示了高度复杂的重组,特别是在具有BAP1,RB1和TP53变异的瘤中. 这种复杂性表明基因组不稳定性和MPM中关键癌症驱动突变之间存在密切联系.

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