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Updated: Jun 30, 2025

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基于纳米载体的基因传递用于免疫细胞工程.

Alireza Gharatape1, Hamid Sadeghi-Abandansari2, Alexander Seifalian3

  • 1Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran. refaridi@sina.tums.ac.ir.

Journal of materials chemistry. B
|March 20, 2024
PubMed
概括

纳米载体为基因修改免疫细胞提供了一个有前途的非病毒替代品,促进了癌症免疫治疗. 本综述探讨了基于纳米粒子的基因传递策略,以提高临床前癌症治疗的效率和安全性.

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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