产前暴露于多环芳和生长参数
Radim J Sram1,2,3, Ivo Solansky1, Anna Pastorkova1
1Institute of Experimental Medicine of the CAS, Prague, Czech Republic.
Journal of applied biomedicine
|March 20, 2024
概括
孕妇暴露于空气中的多环芳 (PAHs) 与不良分娩结果有关. 新生儿尿液中单氧化PAH (OH-PAH) 代谢物的较高水平与减少的长度,胎盘重量和Apgar分数相关,但不是出生体重.
科学领域:
- 环境健康 环境健康
- 围产期流行病学 围产期流行病学
- 毒理学 毒理学 毒理学
背景情况:
- 空气中的多环芳 (PAH) 是已知的环境污染物,可能对怀孕和分娩结果产生不利影响.
- 之前关于PAHs和怀孕结果的研究已经产生了不一致的结果,需要进一步调查.
- 尿中的单氧化PAH (OH-PAH) 代谢物作为PAH暴露的生物标志物.
研究的目的:
- 研究孕妇和新生儿的尿液OH-PAH代谢物水平与各种出生结果之间的关联.
- 为了比较PAH暴露水平及其对出生结果的影响,在两个不同的地区有不同的空气污染水平.
- 为了评估OH-PAH代谢产物与婴儿生长参数之间的关系,直到两岁.
主要方法:
- 这项研究涉及两组2013-2014年出生在捷克共和国的儿童 (Karviná和České Budějovice) 的空气污染水平不同.
- 通过空气中[a]烯 (B[a]P) 度和11种OH-PAH代谢物在母亲和新生儿的尿液水平对PAH暴露的评估.
- 通过医学和儿科问卷收集出生结果数据和婴儿生长参数,直到出生后24个月.
主要成果:
- 在卡尔维纳和冬季观察到更高的B[a]P度和尿液OH-PAH代谢物.
- 在Karviná的新生儿在头三个月内出现了更短的新生儿长度和更少的体重增加.
- 新生儿尿液中OH-PAH代谢物的增加与新生儿长度,胎盘重量和Apgar 5'分数的减少有关,但不是出生体重.
结论:
- 新生儿尿液中OH-PAH代谢物度较高可能与新生儿长度,头周长,胎盘重量和Apgar 5'评分的减少有关.
- 这项研究强调了特定OH-PAH代谢产前暴露与某些不良出生结果之间的可能联系.
- 这些发现强调了在怀孕期间监测环境污染物的重要性,以减轻对婴儿发育的潜在负面影响.
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