Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Complement System01:27

Complement System

2.4K
The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
2.4K
Role of Neurotransmitters in Memory01:23

Role of Neurotransmitters in Memory

548
Neurotransmitters are integral to the brain's communication system, enabling neurons to transmit signals across synapses. This chemical exchange underpins various cognitive functions, including memory processes. The role of neurotransmitters in memory is multifaceted, influencing the encoding, consolidation, and retrieval of memories through their action on different neural circuits.
 Glutamate and Synaptic Plasticity
Glutamate, the brain's main excitatory neurotransmitter, is...
548
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

475
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
475
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

541
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
541
Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

1.3K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
1.3K
The Blood-brain Barrier00:49

The Blood-brain Barrier

47.3K
Overview
47.3K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Shifting From Systemic to Precision-Targeted Complement Therapies: Opportunities and Hurdles.

European journal of immunology·2026
Same author

Dysregulation of complement at the synapse in P301S mice and human tauopathies.

Acta neuropathologica communications·2026
Same author

Lymphocyte alterations and elevated complement signaling are key features of refractory myasthenia gravis.

Med (New York, N.Y.)·2026
Same author

Complement in brain and eye disease: shared mechanisms, convergent pathologies, and common therapeutic opportunities.

Mammalian genome : official journal of the International Mammalian Genome Society·2026
Same author

Activation of the Lectin Pathway Drives Persistent Complement Dysregulation in Long COVID.

Immunology·2026
Same author

<i>HLA's</i> hidden hand in Alzheimer's disease-five research questions en route to an answer.

Brain communications·2025

相关实验视频

Updated: Jun 30, 2025

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

11.8K

神经退行性疾病中的补充系统.

Jacqui Nimmo1, Robert A J Byrne1, Nikoleta Daskoulidou1

  • 1UK Dementia Research Institute Cardiff, Cardiff University, Cardiff CF24 4HQ, U.K.

Clinical science (London, England : 1979)
|March 20, 2024
PubMed
概括
此摘要是机器生成的。

补体系统驱动神经系统疾病的炎症,如阿尔茨海默病,帕金森病,精神分裂症和多发性硬化症. 向补充剂可能为这些疾病提供新的治疗方法.

关键词:
补充补充补充补充补充补充补充.痴呆症 痴呆症是一种痴呆症.这是一种炎症炎症炎症炎症.

更多相关视频

A Model of Epileptogenesis in Rhinal Cortex-Hippocampus Organotypic Slice Cultures
10:05

A Model of Epileptogenesis in Rhinal Cortex-Hippocampus Organotypic Slice Cultures

Published on: March 18, 2021

6.9K
A Novel In Vitro Live-imaging Assay of Astrocyte-mediated Phagocytosis Using pH Indicator-conjugated Synaptosomes
06:43

A Novel In Vitro Live-imaging Assay of Astrocyte-mediated Phagocytosis Using pH Indicator-conjugated Synaptosomes

Published on: February 5, 2018

12.2K

相关实验视频

Last Updated: Jun 30, 2025

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

11.8K
A Model of Epileptogenesis in Rhinal Cortex-Hippocampus Organotypic Slice Cultures
10:05

A Model of Epileptogenesis in Rhinal Cortex-Hippocampus Organotypic Slice Cultures

Published on: March 18, 2021

6.9K
A Novel In Vitro Live-imaging Assay of Astrocyte-mediated Phagocytosis Using pH Indicator-conjugated Synaptosomes
06:43

A Novel In Vitro Live-imaging Assay of Astrocyte-mediated Phagocytosis Using pH Indicator-conjugated Synaptosomes

Published on: February 5, 2018

12.2K

科学领域:

  • 免疫学 免疫学 免疫学
  • 神经科学是一个神经科学.
  • 病理学 病理学 病理学

背景情况:

  • 补体系统对于天生的免疫力和清除免疫复合体至关重要.
  • 适当调节补充介导炎症对于其保护功能至关重要.
  • 不调节的补充激活有助于各种疾病的病理性炎症,包括神经系统疾病.

研究的目的:

  • 审查涉及神经退行性疾病中补充系统的证据.
  • 专注于阿尔茨海默病,帕金森病,精神分裂症和多发性硬化症.
  • 简要讨论反补充药物的治疗潜力和挑战.

主要方法:

  • 关于研究补充剂在神经疾病中的作用的文献综述.
  • 分析证据,将补充激活与疾病病理学联系起来.
  • 讨论潜在的抗补剂药物治疗方法.

主要成果:

  • 越来越多的证据表明补充系统与神经炎症和神经退行性疾病有关.
  • 补充在阿尔茨海默病,帕金森病,精神分裂症和多发性硬化症中起作用.
  • 神经退行是这些不同的神经疾病的重要特征.

结论:

  • 补体系统是多种神经疾病病理学的关键驱动因素.
  • 准补充系统为神经退行性疾病提供了潜在的治疗策略.
  • 需要进一步的研究才能充分了解抗补剂疗法的治疗潜力和陷.