短期血压变化的预后相关性. 西班牙ABPM注册表的西班牙ABPM注册表
Alejandro de la Sierra1, Bryan Williams2, Michael Bursztyn3
1Department of Internal Medicine, Hospital Mutua Terrassa, University of Barcelona, Spain (A.S.).
Hypertension (Dallas, Tex. : 1979)
|March 20, 2024
概括
短期血压变化,血压波动的度量,与高血压患者的死亡风险增加有显著联系. 这一发现强调了其在管理高血压患者的预后价值.
科学领域:
- 心脏病学 心脏病学
- 高血压研究 高血压研究
- 临床流行病学临床流行病学
背景情况:
- 高血压中短期血压 (BP) 变化的预后意义尚不清楚.
- 评估血压变化和死亡率之间的关联对于患者的治疗结果至关重要.
研究的目的:
- 评估短期血压变化与所有原因和心血管死亡率之间的关系.
- 在大量高血压患者中调查预后标志物.
主要方法:
- 分析了来自西班牙门诊血压监测注册表 (2004-2014) 的59,124名患者.
- 从24小时的门诊血压监测中计算各种血压变化指标 (SD,变化系数,加权SD,平均真实变化,血压变化比率).
- 考克斯回归模型被用于评估与死亡率的关联,并根据混因素和血压水平进行调整.
主要成果:
- 血压变化较高的患者表现出全因和心血管死亡率的增加.
- 一些血压变化指标,包括心和心白天和加权SD/变化系数,平均真实变化和心夜间SD,与死亡率有显著的关联.
- 日间SD (≥13 mmHg),夜间SD (≥12 mmHg),加权SD (≥12 mmHg) 和平均真实变异性 (≥10 mmHg) 的特定值独立地与死亡率有关.
结论:
- 短期血压变化显示出与高血压患者的全因和心血管死亡率有着显著的,尽管很小的关联.
- 这些发现强调了在风险分层和高血压管理中考虑BP变化的重要性.
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