糖尿病患者和没有糖尿病患者肝脏相关死亡率的时间趋势:基于人口的研究结果
Stefano Ciardullo1,2, Gabriella Morabito3,4, Federico Rea3,4
1Department of Medicine and Rehabilitation, Policlinico di Monza, Monza, 20900, Italy.
The Journal of clinical endocrinology and metabolism
|March 20, 2024
概括
糖尿病患者的肝病死亡率下降,但非病毒性非酒精性原因现在是主要因素. 糖尿病患者肝脏问题的过度死亡风险保持不变.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 糖尿病学 糖尿病学
- 公共卫生 公共卫生
背景情况:
- 糖尿病显著增加了与肝脏相关的死亡风险.
- 糖尿病人群中肝病死亡率的最近趋势尚不清楚.
研究的目的:
- 分析因具体原因与肝脏相关的死亡率的时间趋势.
- 为了比较意大利糖尿病人和非糖尿病人的死亡率.
主要方法:
- 使用的伦巴第,意大利的医疗保健利用数据库 (2010-2019).
- 计算每年因特定原因死亡率和比例死亡率.
- 将与肝脏有关的死亡归类为病毒性,与酒精有关的和非病毒性非酒精性 (NVNA) 原因.
主要成果:
- 2019年,肝脏疾病占糖尿病患者死亡的2%,非糖尿病患者死亡的1%.
- 糖尿病患者肝脏疾病的原始死亡率从每1000人年 (2010-2019) 的1.13降至0.64.
- 作为肝脏死亡的比例,NVNA原因增加了 (63%至68%),而病毒原因减少了 (27%至23%).
- 在糖尿病患者中,标准化死亡率显示NVNA,病毒性肝炎和酒精性肝病的风险明显更高,随着时间的推移保持稳定.
- 糖尿病患者因肝脏相关原因的过度死亡风险超过了心血管疾病和癌症的风险.
结论:
- 糖尿病患者的肝脏相关死亡率有所下降,但NVNA原因占主导病因.
- 与对照人群相比,糖尿病患者的肝病相关的死亡风险增加在整个研究期间保持一致.
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