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Updated: Jun 30, 2025

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MADD通过Rab27a激活来调节自然杀手细胞降粒

Michael J Medlyn1, Easton Maeder2, Claire Bradley1

  • 1Department of Immunology College of Medicine, Mayo Clinic, Rochester, MN 55905, USA.

Journal of cell science
|March 20, 2024
PubMed
概括

MADD对于激活Rab27a至关重要,Rab27a是自然杀手 (NK) 细胞脱粒化所必需的蛋白质. 缺乏MADD会影响NK和CD8+T细胞的杀死,突出显示MADD在细胞毒性淋巴细胞功能中的作用.

关键词:
在 CD8+ T 细胞中.Degranulation 是一种降粒的方法.这是一种Lytic颗粒.自然杀手细胞是什么?在 Rab27a 中,

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