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Unsymmetric Bending - Angle of Neutral Axis01:15

Unsymmetric Bending - Angle of Neutral Axis

303
Unsymmetrical bending occurs when a structural member is subjected to bending moments in a plane that does not align with the member's principal axes. This scenario typically arises in beams and other structural components when loads are applied at non-ideal angles, introducing complexities in stress analysis.
When a bending moment is applied at an angle θ concerning the vertical axis of a symmetrical member, it can be resolved into components along the member's principal...
303
Generation of Straight or Branched Actin Filaments01:14

Generation of Straight or Branched Actin Filaments

2.9K
The straight or branched structure formation of actin filaments is controlled by nucleating proteins such as the formins and Arp2/3 complex. Formin-mediated assembly results in straight filaments, whereas Arp2/3 protein complex-mediated assembly results in branched actin filaments.
Arp2/3 Complex
Arp2/3 complex is a seven-subunit complex consisting of two proteins similar to actin- Arp2 and Arp3, and five other subunits that help keep Arp2 and Arp3 inactive. When required, the complex is...
2.9K
Protein Folding01:22

Protein Folding

118.1K
Overview
118.1K
Normal Strain under Axial Loading01:20

Normal Strain under Axial Loading

470
Normal strain under axial loading is an important concept in the field of mechanics of materials. Axial loading implies the application of a force along the axis of a material, like a column or bar. This force can either compress or stretch the material. In the context of axial loading, normal strain is the deformation experienced by the material in the direction of the loading force. It's calculated as the change in length divided by the original length of the material. This unitless ratio...
470
Tension01:10

Tension

12.1K
Tension is a force along the length of a medium, in particular, a force carried by a flexible medium, such as a rope or cable. The word "tension" comes from Latin, meaning "to stretch". Not coincidentally, the flexible cords that carry muscle forces to other parts of the body are called tendons. Any flexible connector, such as a string, rope, chain, wire, or cable, can exert pull only parallel to its length; so, a force carried by a flexible connector is a tension with a...
12.1K
Mechanisms of Membrane-bending01:15

Mechanisms of Membrane-bending

2.7K
The living membranes are flexible due to their fluid mosaic nature; however, their bending into different shapes is an active process regulated by specific lipids and proteins. The membrane bending can be transient as seen in vesicles or stable for a long time as in microvilli. Cells regulate the size, location, and duration of the membrane curvature.
Membrane bending can happen due to intrinsic changes in lipid composition or extrinsic association with different proteins. The proteins involved...
2.7K

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相关实验视频

Updated: Jun 30, 2025

A Novel Stretching Platform for Applications in Cell and Tissue Mechanobiology
16:46

A Novel Stretching Platform for Applications in Cell and Tissue Mechanobiology

Published on: June 3, 2014

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轴突张力有助于保持一致的折叠位置.

Xincheng Wang1, Shuolun Wang1, Maria A Holland1,2

  • 1Department of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN 46556, USA. maria-holland@nd.edu.

Soft matter
|March 20, 2024
PubMed
概括
此摘要是机器生成的。

轴突紧张,而不仅仅是差异生长,可以驱动大脑折叠位置. 这项研究引入了一个新的模型,显示轴突张力是皮层折叠模式的关键因素.

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Mechanical Manipulation of Neurons to Control Axonal Development
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Axon Stretch Growth: The Mechanotransduction of Neuronal Growth

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相关实验视频

Last Updated: Jun 30, 2025

A Novel Stretching Platform for Applications in Cell and Tissue Mechanobiology
16:46

A Novel Stretching Platform for Applications in Cell and Tissue Mechanobiology

Published on: June 3, 2014

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Mechanical Manipulation of Neurons to Control Axonal Development
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Mechanical Manipulation of Neurons to Control Axonal Development

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Axon Stretch Growth: The Mechanotransduction of Neuronal Growth
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Axon Stretch Growth: The Mechanotransduction of Neuronal Growth

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科学领域:

  • 神经科学是一个神经科学.
  • 发展生物学 发展生物学
  • 计算生物学 计算生物学

背景情况:

  • 皮层折叠对大脑发育至关重要,它创造了特定物种和个体的大脑结构.
  • 现有的计算模型,主要是基于差异增长,努力解释皮质折叠的确切位置.
  • 轴突张力假设提供了一个潜在的解释,但其在旋转中的作用仍然存在争议.

研究的目的:

  • 通过开发一种新的计算模型,研究轴突张力在皮层折叠中的作用.
  • 将轴突张力假设与微分生长理论结合起来,以更好地理解化.
  • 为了确定轴突张力是否会影响皮质的位置和模式.

主要方法:

  • 开发了一种新的双层有限元素模型.
  • 结合了分泌皮质生长和特征性轴突张力在皮质下.
  • 模拟了轴突张力和几何扰动对皮层折叠模式的影响.

主要成果:

  • 轴突张力作为一种干扰,可以触发曲并确定折叠位置.
  • 轴承张力可以克服典型的厚度扰动,决定折叠位置.
  • 轴突刚性的异质性显著改变皮质折叠模式,突出显示白质连接的重要性.

结论:

  • 轴突张力是确定皮质折叠位置的关键因素,补充了差异生长理论.
  • 结合轴突张力的计算模型为化机制提供了新的见解.
  • 进一步研究轴突连接在大脑发育和折叠中的作用是有必要的.