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在无症状动脉狭窄症患者中,对大脑结构变化的宏观和微血管贡献

Lena Schmitzer^1,2,3, Stephan Kaczmarz^1,2,3,4, Jens Göttler^1,2,3

¹Department of Diagnostic and Interventional Neuroradiology, School of Medicine, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

|March 20, 2024

概括

内动脉狭窄 (ICAS) 与小血管疾病 (SVD) 和中风风险有关. 这项研究发现SVD影响大脑结构和血液流动,ICAS患者观察到的ipsilateral和contralateral变化.

科学领域:

神经成像是一种神经成像.
脑血管疾病脑血管疾病
神经学神经学

背景情况:

内动脉狭窄 (ICAS) 是缺血性中风的重要危险因素.
小血管疾病 (SVD) 经常与ICAS同时发生,并导致脑血管病理.
了解ICAS,SVD和大脑变化之间的相互作用对于预防中风至关重要.

研究的目的:

为了研究与SVD相关的血液动力学和结构性大脑变化,在单边无症状ICAS患者中.
要区分ICAS和SVD对大脑指标的ipsilateral和contralateral影响.
探索SVD标志物与白质变化,皮质厚度和脑血流之间的关系.

主要方法:

利用先进的磁共振成像 (MRI) 技术,包括扩散张力成像 (DTI) 和伪连续动脉旋转标记.
使用自由水 (FW) 和骨架化平均扩散率 (PSMD) 的峰值宽度在FW纠正的DTI上评估了与SVD相关的变化.
在28名ICAS患者和30名对照人群中分析了皮层厚度,脑血流 (CBF) 和毛细血管过路时间异质性 (CTH).

主要成果:

在ICAS患者身上,后背环状皮质和极狭窄后侧的皮质厚度降低.
在ICAS患者中观察到高PSMD和FW,表明与SVD相关的白质变化.
在白质中发现了显著的横向CBF和横向CTH的趋势,在FW校正的DTI指标中存在相反的变化.

结论:

在ICAS患者的大脑中,SVD与明显的结构和血液动力学变化有关.
这些发现表明,SVD有助于白质变化,并可能影响全球大脑变化以及ICAS相关的血液动力学效应.
这些结果突出了ICAS中复杂的脑血管病理,并强调了在中风风险评估中考虑SVD的重要性.

关键词:

无症状的内 Carotid 动脉狭窄.动脉旋转标签的标记脑血管疾病脑血管疾病扩散张力成像的成像方法小血管疾病是小血管疾病.

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