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在使用自动化胰岛素输送系统的1型糖尿病老年患者中,与低于范围的时间增加相关的特征
Ana María Gómez Medina1, Darío A Parra Prieto1, Diana Cristina Henao Carrillo1
1Hospital Universitario San Ignacio and Pontificia Universidad Javeriana, Bogotá, Colombia.
Journal of diabetes science and technology
|March 20, 2024
概括
在使用自动胰岛素输送的1型糖尿病老年患者中,较低的肌肉质量,握力和内脏脂肪与较高的低血糖风险有关. 老年人的评估是个性化管理的关键.
科学领域:
- 内分泌学 在内分泌学.
- 老年病的医生 老年病的医生
- 代谢疾病 代谢疾病
背景情况:
- 使用自动胰岛素输送系统 (AID) 的1型糖尿病 (T1D) 的老年患者面临着独特的挑战,包括降血糖的风险增加.
- 了解导致这种风险的因素对于优化治疗和改善患者治疗结果至关重要.
研究的目的:
- 用AID系统调查与老年T1D患者低血糖风险增加相关的特征.
- 探索身体构成,老年学评估结果和血糖控制之间的关联,特别是时间低于范围 (TBR).
主要方法:
- 一项横截面的观察性研究包括59名60岁以上的患者,他们使用传感器增强型胰岛素治疗与预测性低血糖管理 (SAPT-PLGM),混合闭环 (HCL) 或高级混合闭环 (AHCL) 超过三个月.
- 进行了老年评估和身体组成分析,以评估与实现TBR目标 (<70 mg/dL) 的关联.
主要成果:
- 患有高TBR (<70 mg/dL>1%) 的患者表现出更高的HbA1c,更低的时间范围 (TIR),更高的时间超出范围 (TAR) 和高的血糖变异性.
- 更大的肌肉质量,握力和内脏脂肪与较低的TBR (<70 mg/dL) 有关.
- 与SAPT-PLGM和HCL系统相比,先进的混合闭环 (AHCL) 系统的使用时间 (TIR) 更长.
结论:
- 在接受AID治疗的老年T1D患者中,较低的肌肉质量,握力和内脏脂肪百分比与低血糖风险增加有关 (TBR>1%),无论使用哪种特定的AID技术.
- 血糖控制指标,如HbA1c,TIR,TAR和血糖变化也与低血糖风险有关.
- 综合老年人评估对于定制管理策略在这个人群中至关重要.
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