相关实验视频

Updated: Jun 30, 2025

Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives

Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives

Published on: February 7, 2017

嵌合体 π-丰富的共价有机框架使结合聚合物中的性印记成为可能:从头开始限制聚合和性记忆

Xiaofeng Zhang¹, Xinfa Chen¹, Shiguo Fu¹

¹School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules and State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, Shanghai, 200240, China.

Angewandte Chemie (International ed. in English)

|March 20, 2024

概括

研究人员开发了一种新型模板合成光学活性π合聚合物 (OACP) 的新型模板合成方法,使用了合共价有机框架 (CCOF). 这种方法将性印记在聚合物中,使得有效的反分离和推进功能材料.

科学领域:

材料科学材料科学材料科学
聚合物化学聚合物化学
超分子化学超分子化学

背景情况:

光学活性π合聚合物 (OACPs) 对于与性相关的功能至关重要,模仿生物螺旋.
传统的合成依赖于复杂的有机方法,将性侧组附加到性聚合物上.

研究的目的:

引入一种新的,高效的合成非替代OACP的方法.
展示使用合共价有机框架 (CCOFs) 作为在聚合物中合印记的模板.

主要方法:

模板合成使用CCOF纳米孔内的achiral单体的超分子封闭聚合.
利用CCOFs的奇拉纳米空间来诱导enantiospecific聚合和自我传播.
描述由此产生的OACP对于合性记忆和反歧视能力的特征.

主要成果:

在CCOF模板中实现了in situ enantiospecific聚合和奇拉印记,类似于非酶性PCR系统.
合成的OACP,即使在从模板中释放和在高达200°C的温度下进行热处理后,也保留了奇拉信息.
通过OACPs证明了强大的enantiodiscrimination,成功地分离了高达85%的余 (ee) 的raceme氨基酸.

结论:

CCOFs作为有效的模板,可以在超分子级上对联聚合物打印光学活性.
这种方法为合成进化和探索先进的功能性OACP提供了途径.
开发的方法为制造性聚合物提供了一个有前途的途径,在enantioseparation和超越应用中具有应用.

关键词:

性记忆性记忆是一种体内记忆.奇拉性印记打印方式结合聚合物的聚合物.协价有机框架协价有机框架通过enantioselective分离进行分离.

更多相关视频

Microfluidic-based Synthesis of Covalent Organic Frameworks COFs: A Tool for Continuous Production of COF Fibers and Direct Printing on a Surface

Microfluidic-based Synthesis of Covalent Organic Frameworks COFs: A Tool for Continuous Production of COF Fibers and Direct Printing on a Surface

Published on: July 10, 2017

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs

Published on: January 17, 2020

相关概念视频

Prochirality

Prochirality

The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...

Molecules with Multiple Chiral Centers

Molecules with Multiple Chiral Centers

Molecules that possess multiple chiral centers can afford a large number of stereoisomers. For instance, while some molecules like 2-butanol have one chiral center, defined as a tetrahedral carbon atom with four different substituents attached, several molecules like butane-2,3-diol have multiple chiral centers. A simple formula to predict the number of stereoisomers possible for a molecule with n chiral centers is 2n. However, there can be a lower number where some of the stereoisomers are...

Chirality

Chirality

Chirality is a term that describes the lack of mirror symmetry in an object. In other words, chiral objects cannot be superposed on their mirror images. For example, our feet are chiral, as the mirror image of the left foot, the right foot, cannot be superposed on the left foot.
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...

Polymer Classification: Stereospecificity

Polymer Classification: Stereospecificity

Polymerization generates chiral centers along the entire backbone of a polymer chain. Accordingly, the stereochemistry of the substituent group has a significant effect on polymer properties. Polymers formed from monosubstituted alkene monomers feature chiral carbons at every alternate position in the polymer backbone. Relative to the predominant orientation of substituents at the adjacent chiral carbons, the polymer can exist in three different configurations: isotactic, syndiotactic, and...

Stereoisomerism of Cyclic Compounds

Stereoisomerism of Cyclic Compounds

In this lesson, we delve into the role of ring conformation and its stability, which determines the spatial arrangement and, consequently, the molecular symmetry and stereoisomerism of cyclic compounds. 1,2-Dimethylcyclohexane is used as a case study to evaluate the possible number of stereoisomers. Here, given the multiple (n = 2) chiral centers, there are 2n = 4 possible configurations that lack a plane of symmetry, as the ring skeleton exists in a non-planar chair conformation. In addition,...

Olefin Metathesis Polymerization: Ring-Opening Metathesis Polymerization (ROMP)

Olefin Metathesis Polymerization: Ring-Opening Metathesis Polymerization (ROMP)

Ring-opening metathesis polymerization or ROMP involves strained cycloalkenes as starting materials. The mechanism of ROMP proceeds by reacting cycloalkene with Grubbs catalyst to give metallacyclobutane intermediate which undergoes a ring-opening reaction to form new carbene. The new carbene reacts with another molecule of cycloalkene. Repetition of these steps leads to the formation of an unsaturated open-chain polymer product. All these steps are reversible, however, relieving the ring...