相关实验视频

Updated: Jun 30, 2025

Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach

Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach

Published on: May 2, 2018

肠道微生物群和MDSC之间的交互会促进结肠炎相关的癌症发展

Hadas Ashkenazi-Preiser¹, Or Reuven¹, Atara Uzan-Yulzari²

¹The Concern Foundation Laboratories at The Lautenberg Center for Immunology and Cancer Research, Israel-Canada Medical Research Institute, Faculty of Medicine, The Hebrew University, POB 12272, Jerusalem 91120, Israel.

Cancer research communications

|March 20, 2024

概括

骨髓衍生抑制细胞 (MDSC) 和肠道细菌的相互作用促进结直肠癌. 破坏这些相互作用可以减少炎症和瘤生长,提供新的治疗点.

科学领域:

免疫学免疫学免疫学
微生物学微生物学
在瘤学瘤学.

背景情况:

慢性肠道炎症与微生物失衡和免疫细胞积累有关,增加结直肠癌的风险.
骨髓原抑制细胞 (MDSC) 是关键的免疫细胞,在结肠炎相关结肠直肠癌 (CAC) 中影响瘤微环境.
在CAC病变发生过程中,MDSCs与异生物微生物群之间的确切相互作用尚未完全理解.

研究的目的:

在CAC.的小鼠模型中调查MDSCs和异生物微生物群之间的复杂交谈.
阐明这些相互作用对肠道炎症,免疫抑制和瘤发展的影响.
确定针对MDSC-细菌相互作用的潜在治疗策略,用于CAC治疗.

主要方法:

利用大肠炎相关结直肠癌 (CAC) 的小鼠模型.
进行抗生素治疗以破坏MDSC-微生物群相互作用.
分析了肠道炎症,MDSC水平,免疫抑制和瘤负担的变化.
研究了细菌对MDSC抑制功能和分化的影响.

主要成果:

携带CAC的小鼠显示免疫抑制MDSCs的升高以及微生物群组成的改变.
抗生素治疗显著降低了肠道炎症,MDSC水平和瘤负担.
发现异生物微生物群在瘤发育中起着起因作用.
细菌被证明可以增强MDSC抑制活性并改变髓状细胞分化.

结论:

瘤微环境中的MDSC-细菌交叉交谈是CAC进展的关键驱动因素.
准MDSC-微生物群相互作用为CAC提供了一个有前途的治疗途径.
异生菌微生物群可以作为CAC中瘤负载的预测生物标志物.

更多相关视频

Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice

Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice

Published on: March 10, 2015

Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells

Development of an Antigen-driven Colitis Model to Study Presentation of Antigens by Antigen Presenting Cells to T Cells

Published on: September 18, 2016

相关概念视频

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

Renewal of Intestinal Stem Cells

Renewal of Intestinal Stem Cells

The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...