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Updated: Jun 30, 2025

Co-Culture of Murine Small Intestine Epithelial Organoids with Innate Lymphoid Cells
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食纤维是病理性ILC2反应和肠道炎症的关键决定因素

Mohammad Arifuzzaman1,2,3,4, Tae Hyung Won5, Hiroshi Yano1,2,3,4

  • 1Jill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University , New York, NY, USA.

The Journal of experimental medicine
|March 20, 2024
PubMed
概括

食纤维改变肠道细菌,产生胆酸,驱动先天性淋巴细胞 (ILC) 中的炎症反应. 这一途径加剧肠道炎症,并与人类炎症性肠病 (IBD) 有关.

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
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Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
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