循环中的多可萨赫萨酸和所有原因和特定原因死亡率的风险
Evan L O'Keefe1, James H O'Keefe1, Nathan L Tintle2
1Saint Luke's Mid America Heart Institute and University of Missouri-Kansas City, Kansas City, MO, USA.
Mayo Clinic proceedings
|March 20, 2024
概括
较高水平的多科萨赫萨酸 (DHA) 是一种omega-3脂肪酸,与显著降低所有死因,心血管疾病和癌症的死亡风险有关. 这种海洋营养素可能支持更长,更健康的生活.
科学领域:
- 营养科学 营养科学
- 心血管健康 心血管健康
- 流行病学 流行病学
背景情况:
- 多可萨赫萨酸 (DHA) 是一种海洋欧米茄-3脂肪酸,对各种身体功能至关重要.
- 调查DHA水平与死亡率之间的长期关联对公共卫生至关重要.
- 之前的研究表明潜在的好处,但需要大规模的长期数据.
研究的目的:
- 调查循环DHA水平与所有原因,心血管 (CV) 和癌症死亡率的长期风险之间的联系.
- 评估DHA对整体寿命和特定死亡原因的影响.
主要方法:
- 分析了来自英国生物库队列 (117,702名受试者) 的数据,分析了血DHA水平和死亡率的随访.
- 结合英国生物库数据与FORCE联盟 (17个队列,42,702个人) 的元分析,共计160,404名参与者.
- 对DHA水平的五分位数进行了死亡风险评估,并根据相关风险因素进行了调整.
主要成果:
- 较高的血DHA水平与英国生物银行队列中所有原因死亡风险降低21%有关.
- 在综合分析中,较高的DHA水平与17%较低的全因死亡风险相关.
- 对于心血管疾病 (21%),癌症 (17%) 和其他原因 (15%) 的死亡风险有显著降低,DHA水平较高.
结论:
- 较高的DHA水平与所有原因死亡率的降低显著相关.
- 摄入DHA可能有助于降低心血管疾病和癌症的死亡风险.
- 这些发现支持了海洋来源的DHA有助于心血管健康和寿命的假设.
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