在中国患者中,自然史和眼进展的危险因素与正常张力眼的中国患者
De-Fu Chen1,2, Chenmin Wang1,2, Yuqing Si1,2
1National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Investigative ophthalmology & visual science
|March 20, 2024
概括
超过60%的中国患者患有正常张力玻璃眼 (NTG) 在大约70个月的时间内表现出疾病进展. NTG进展的关键预测因素包括磁盘出血,女性性别和较高的眼内压力 (IOP).
科学领域:
- 眼科和眼镜检查的眼科和眼镜检查.
- 玻璃眼研究研究 玻璃眼研究
- 临床流行病学临床流行病学
背景情况:
- 正常张力玻璃眼 (NTG) 是全球不可逆转失明的重要原因之一.
- 了解NTG在不同人群中的自然史和进展因素对于有效管理至关重要.
- 中国患者代表了一个独特的人口群体,其中NTG特征可能有所不同.
研究的目的:
- 在一组中国患者中,描述正常张力青光眼 (NTG) 的自然史.
- 确定未经治疗的NTG中功能和结构进展的预测因素.
主要方法:
- 对新诊断NTG的未经治疗的中国患者进行前性观察队列研究.
- 随访的最低持续时间为2年.
- 通过视野 (VF) 恶化评估的功能性进展;通过视网膜神经纤维层 (RNFL) 或状细胞内状层 (GCIPL) 稀薄的结构性进展.
主要成果:
- 84名参与者的63.1%在平均69.7个月的随访期间取得了进展.
- 视野进展发生在29.8%,而RNFL/GCIPL稀释发生在48.8%.
- 进展的重要预测因素包括磁盘出血 (HR 2.82),女性性别 (HR 1.98) 和平均眼内压力 (IOP) (HR 1.14每毫米升). 较长的轴长度 (AL) 保护了VF的进展,较高的最低透析血压 (DBP) 保护了结构性进展.
结论:
- 在未经治疗的中国NTG患者中,很大一部分患者在平均70个月的随访期间经历了疾病进展.
- 磁盘出血,女性性别,升高的平均内压,较短的轴长度和较低的最小透气血压是NTG进展的重要预测因素.
- 这些发现凸显了中国NTG患者监测和风险分层的重要性.
相关概念视频
01:25Glaucoma: Overview
566
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
566
01:27Open Angle Glaucoma: Treatment
444
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
444
01:28Angle Closure Glaucoma: Treatment
488
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
488
01:22Photoreceptors and Visual Pathways
6.0K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
6.0K