[非IgE介导的食物过敏]
María Isabel Rojo Gutiérrez1, Diego Ballesteros González2, Ana Karen Ortiz Durán3
1Alergóloga e Inmunóloga clínica, Máster en Ciencias y Educación; Miembro de la Mesa Directiva de SLAAI; miembro activo del Colegio Mexicano de Inmunología Clínica y Alergia; Directora de Alergología en la Unidad Médica Zúrich, Ciudad de México.mi_rojo@yahoo.com.
概括
食物过敏涉及对食物蛋白质的免疫反应,影响肠道. 便微生物种植提供了一种有效的方法,通过改变肠道微生态来管理这些过敏.
科学领域:
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
- 微生物学 微生物学
背景情况:
- 食物过敏是一种对食物蛋白质的免疫反应,影响8%的儿童和2%的成年人.
- 非IgE介导的食物过敏主要影响胃肠道.
- 胃肠道食物过敏被分为IgE介导,非IgE介导或混合.
研究的目的:
- 审查非IgE介导的胃肠道食物过敏的分类和表现.
- 讨论在食物蛋白诱导肠道炎综合征,肠道病变和肠直肠炎中的亚托皮性疾病的作用.
- 探索益生菌和便微生物群移植 (FMT) 在管理这些疾病中的治疗潜力.
主要方法:
- 对非IgE介导的胃肠道食物过敏的文献综述.
- 临床表现和病变发生的分析.
- 评估包括益生菌和FMT在内的治疗选择.
主要成果:
- 食物蛋白质诱导的过敏性透肠炎在新生儿中表现为偏远结肠炎症和血.
- 食物蛋白诱发性肠球炎综合征是一种非IgE介导的过敏,会导致长时间的吐,特别是在成年人摄入贝类后.
- 在患有食物蛋白诱导肠道炎综合征,肠道病变和肠直肠炎的患者中,亚托皮性疾病很普遍.
结论:
- 像Lactobacillus GG这样的益生菌可以通过调节肠道微生物群来缓解食物蛋白引起的过敏性肠道炎的症状.
- 便微生物种移植 (FMT) 与饮食改变或益生菌相比,为改变肠道微生态提供了一种有效的方法.
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