个性化急性胰腺炎预后的代谢评分工具:一个多中心分析
Shi-Jun Chen1, Shu-Ling Wang2, Chun-Sen Chen3
1Department of Critical Care Medicine, Affiliated Hospital of Putian University, Putian, China.
Biomolecules & biomedicine
|March 20, 2024
概括
身体组成的变化,特别是骨肌肉指数 (ΔSMI) 和骨肌肉辐射密度 (PreSMR) 的差异,可以预测急性胰腺炎 (AP) 的严重程度. 这些标志物有助于为AP患者制定个性化治疗策略.
科学领域:
- 医学科学 医学科学 医学科学
- 胃肠病学 胃肠病学
- 身体组成分析 身体成分分析
背景情况:
- 急性胰腺炎 (AP) 的严重程度与人体组成有关.
- 对AP严重性的预测标记对于患者管理至关重要.
研究的目的:
- 评估身体组成参数对AP严重性的预测值.
- 根据人体成分开发一个评估AP严重性的模型.
主要方法:
- 对213名AP患者 (AHOPTU) 的身体成分数据 (ΔSMI,PreSMR) 的分析和173名AP患者 (FMUUH) 的验证.
- 将患者分为不严重和严重的AP组.
- 开发一个使用后勤回归和最佳切线值的评分系统 (SMS).
主要成果:
- 较低的PreSMR和较高的ΔSMI与非严重的AP相关.
- ΔSMI 和 PreSMR 被确定为AP严重性的独立风险因素.
- 开发的SMS显示出良好的预测性能 (AUC为0.764和0.741).
结论:
- 骨肌肉指数变化和放射密度是AP严重程度的可靠预测因素.
- 拟议的预测模型可以帮助个人化治疗规划AP患者.
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