从使用瓜拉纳提取物作为咖啡因来源的电子烟烟雾中成分的LC-MS/MS分析
Suzuna Saruwatari1, Makoto Takada1,2, Junpei Mutoh1
1Faculty of Pharmaceutical Sciences, Sanyo-Onoda City University, 1-1-1 Daigakudori, Sanyo-Onoda, Yamaguchi, 756-0884, Japan.
概括
使用瓜拉纳提取物 (GE) 的咖啡因 (Caf) 电子烟显示,加热加速了Caf的降解到相关组件. 在烟雾中发现了epicatechin,但在电子液体中没有发现,这表明了热转化.
科学领域:
- 分析化学 分析化学
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
背景情况:
- 含有来自瓜拉那提取物 (GE) 的咖啡因 (Caf) 的电子烟越来越受欢迎.
- 了解电子烟烟雾的化学成分对于评估潜在的健康风险至关重要.
研究的目的:
- 分析含有转基因电子烟的电子液体和香烟烟雾提取物 (CSE) 中的咖啡因及其相关化合物 (红素,红素,素) 的度.
- 研究电子烟使用过程中咖啡因和其他GE成分的热降解途径.
主要方法:
- 液体染色学-双重质谱法 (LC-MS/MS) 用于组件分析.
- 在电子液体和CSE中对咖啡因,神胺 (TB),神素 (TP) 和素 (PX) 的定量分析.
- 电子液体和CSE之间的组件度和峰值面积比率的比较.
主要成果:
- 对Caf,TB,TP和PX的度范围在电子液体和CSE中确定.
- 在含有转基因的电子烟中观察到CAF与相关化合物的加快热降解.
- 在CSE中检测到GE成分Epicatechin,但在电子液体中没有,这表明热转换.
结论:
- 使用GE电子烟导致咖啡因及其代谢物的显著热降解.
- 在CSE中存在epicatechin表明其在加热过程中形成或释放.
- 需要进一步的研究来评估这些降解产品的毒理影响.
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