通过单个基底质化荷尔蒙水平检查中心早期青春期的查
Alessandra Li Pomi1, Perla Scalini2, Salvatore De Masi3
1Department of Human Pathology of Adulthood and Childhood, University of Messina, Messina, Italy.
Endocrine
|March 20, 2024
概括
一次基底化激素 (LH) 测量可以帮助排除女孩中部早熟青春期 (CPP). 这一发现有助于诊断下垂体-垂体-腺 (HPG) 轴激活.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 生殖内分泌学 生殖内分泌学
背景情况:
- 中部早发性青春期 (CPP) 是通过确认下丘脑-垂体-腺 (HPG) 轴的激活来诊断的.
- 区分CPP与其他疾病,如早发性异位发作 (PIT) 和早期青春期 (EA),对于适当的管理至关重要.
研究的目的:
- 为了确定基底白化激素 (LH) 水平的切断值.
- 为了确定HPG轴激活在诊断中CPP的指示性骨盆超声波参数.
主要方法:
- 248名怀疑处于早期青春期的女孩接受了GnRH刺激测试.
- 分析了基底血清LH,FSH,LH/FSH比率和盆腔超声波的参数.
- 使用接收器运行曲线 (ROC) 来评估诊断标记的灵敏度和特异性.
主要成果:
- 基底LH水平≥0.14mIU/mL显示出高可预测性 (90.6%的灵敏度,78.2%的特异性).
- 基础LH/FSH比率≥0.1显示了85.9%的灵敏度和78.1%的特异性.
- 子宫长度切线为35毫米,灵敏度为83.5%,但特异性低 (42.9%). 卵巢体积显示出诊断效用较差.
结论:
- 在确定切线以下的一次基底LH测量可能足以排除HPG轴激活.
- 这简化了潜在的CPP病例的诊断过程.
关键词:
诊断 诊断 诊断 诊断 诊断在 GnRH 试验中测试.LH LH LH LH LH LH LH LH LH LH LH LH LH LH流化激素的产生过早的青春期 过早的青春期青春期 青春期 青春期更多相关视频
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